Symbol
Name
ID

Cgas
cyclic GMP-AMP synthase
MGI:2442261

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

abnormal macrophage physiology

decreased circulating interferon-alpha level

decreased circulating interferon-beta level

abnormal dendritic cell physiology

abnormal plasmacytoid dendritic cell physiology

abnormal immune cell physiology

abnormal interferon secretion

increased susceptibility to Herpesvirales infection induced morbidity/mortality

increased susceptibility to Poxviridae infection induced morbidity/mortality

increased susceptibility to Flaviviridae infection induced morbidity/mortality

increased susceptibility to Herpesvirales infection

increased susceptibility to Retroviridae infection

increased susceptibility to Poxviridae infection

increased susceptibility to Flaviviridae infection

Availability

Mouse Genotype

Cgas^{tm1a(EUCOMM)Hmgu}/Cgas^{tm1a(EUCOMM)Hmgu}

Cgas^{tm1d(EUCOMM)Hmgu}/Cgas^{tm1d(EUCOMM)Hmgu}

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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